Ahvaz Jundishapur University of Medical Sciences Jundishapur Journal of Health Sciences 2345-4075 12 2 2020 04 01 The Effect of Six Weeks of High Intensity Interval Training on eNOS and PGC-1α Gene Expression in the Heart Tissue of Male Obese Rats 1 5 225550 10.5812/jjhs.100280 EN Behnoush Ghadery Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Farshad Ghazalian* Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Seyed Ali Hosseini Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Hossein Abed Natanzy Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Alireza Shamsoddini Exercise Physiology Research Center, Research Institute for Life Style, Baqiyatallah University of Medical Sciences, Tehran, Iran Journal Article 2019 12 24 Background: Nowadays, obesity can affect heart function and induced atherosclerosis, high blood pressure, and heart arrhythmia, which has become a major problem for global health. Objectives: The present study aimed to review the effect of six weeks of high-intensity interval training (HIIT) on gene expression levels of PGC-1α and eNOS in the heart tissue of obese male rats. Methods: In this experimental study, 14 high-fat diet (HFD)-induced obese rats were divided into two groups of control and training. Also, 7 rats were placed in a non-obese control group to investigate the effects of obesity on research variables. During six weeks, rats in the training group performed HIIT three days per week. After six weeks, all rats were sacrificed, and their heart tissue was removed to measure the PGC-1α and eNOS gene expression. We used one-way ANOVA with Tukey’s post hoc tests (P ≤ 0.05) for statistical analysis. Results: HFD significantly decreased PGC-1α (P = 0.04) and eNOS (P = 0.001) gene expression, but HIIT significantly increased PGC-1α (P = 001) and eNOS (P = 0.001) gene expression. Conclusions: HIIT seems to improve cardiac gene expression levels of PGC-1α and eNOS of male obese rats. Keywords:eNOS,Heart,Obesity,Training,PGC-1α

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